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Materials Laboratory
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Current Projects
Project
Title:
Studies of dynamics of external urethral sphincter
during micturition of rats
Principal
Investigator: Shyang Chang
Funding
Source:
Abstract:
Instillation
of cold water into the urinary bladder has been used as a diagnostic test to
evaluate neurogenic dysfuctions of the lower urinary tract (LUT). The graph of
the bladder pressure and EUS EMG are obviously different with room temperature
simulation. In the physiologic field, we know that cold temperature stimulate
capsaicin-sensitive C fiber bladder afferents that reflexly activate the EUS,
producing detrusor and EUS dyssynergia and increasing urethral outlet
resistance. We will analyze the normal rats with room-temperature and
cold-temperature stimulation by the modern methods of nonlinear dynamics.
Finally, we will compare the details of the EUS of the above cases during
micturiion in order to acquire the insight. Hence, it will enable us to give
physiological meaning in different cases.
Project
Title:
Studies
of micturition mechanism of rats via chaotic dynamics and fractal theory
Principal
Investigator: Shyang Chang
Funding
Source: National
Science Council (2000/8-2001/7)
Abstract:
The accordant
center of the detrusor and EUS is in the pons. Any injury between pons and
sacral cord will interfere this accordant action. It may not letdown the EUS or
contract effectively during the contraction of the detrusor. So the bladder
can’t empty completely. The graph of the detrusor and the EUS EMG are also
different with the normal animals.In the NSC program last year, we devoted ourselves to
establish the interrelationship between the detrusor and external urethral
sphincter (EUS) of the Wistar rats (the normal rats with room temperature
stimulation, the normal rats with cold stimulation, the rats after SCI). We
then quantitatively analyzed the
variation of three stages (the period before pressure increased, during
micturition, and after micturition) of EUS. In the upcoming year, we will
analyze the micturition mechanism for normal rats with room temperature
stimulation, the normal rats with cold water stimulation, and the rats after
SCI. In order to avoid the insufficiency in traditional methods, we will test
if it is suitable to use the optimal linear model by using surrogate data. We
will then use chaotic dynamics and fractal theory to compare the details of the
EUS of the above cases during micturition in order to acquire the insight.
Hence, it will enable us to give physiological meaning in different cases and
hopefully will help the doctors to diagnose the patients in clinical practice.