Chen, Bor-Sen (陳博現)

$描述: 描述: 描述: C:\Users\Yu-Chao Wang\Desktop\雜物\WWW-bschen\bschenCV.files\image001.jpg$

Chen, Bor-Sen (陳博現)

Tsing Hua Professor of Electrical Engineering and Computer Science

Ph.D., University of Southern California, 1982

System Control, Signal Processing and Communication, Systems Biology

Dr. Bor-Sen Chen received the B.S. degree from Tatung Institute of Technology, Taipei, Taiwan, the M.S. degree from National Central University, Chungli,

Taiwan, and the Ph.D. degree from the University of Southern California, Los Angeles, in 1970, 1973 and 1982, respectively. He was a Lecturer, Associate Professor, and Professor at Tatung Institute of Technology from 1973 to 1987. He is currently the Tsing Hua University Professor of Electrical Engineering and Computer Science at National Tsing Hua University, Hsinchu, Taiwan. His current research interests are in control engineering, signal processing and systems biology. Dr. Chen has received the Distinguished Research Award from the National Science Council of Taiwan four times. He is a Research Fellow of the National Science Council of Taiwan and holds the excellent scholar Chair in engineering. He has also received the Automatic Control Medal from the Automatic Control Society of Taiwan in 2001. He is an Associate Editor of the IEEE Transactions on Fuzzy Systems from 2001 to 2006 and Editor of the Asian Journal of Control. He is a Member of the Editorial Advisory Board of Fuzzy Sets and Systems and the International Journal of Control, Automotion and Systems. He is the Editor in Chief of International Journal of Fuzzy Systems from 2005 to 2008. He is a Fellow of IEEE.

陳博現教授

一、個人基本資料

中文姓名：陳博現	英文姓名：Bor-Sen Chen
E-Mail: bschen@ee.nthu.edu.tw
個人網站：http://www.ee.nthu.edu.tw/bschen/
聯絡地址： (30013) 新竹市清華大學電機工程學系
聯絡電話：(03)573-1155 傳真號碼：(03)571-5971

二、學歷

1.大同工學院電機工程學士 1970

2.中央大學地球物理碩士 1973

3.美國南加州大學電機博士 1982

三、經歷

服務機關	職稱	起迄時間
大同工學院	電機系講師，副教授，教授	1973-1987
清華大學電機系	教授	1987-迄今

四、 國際學術服務

服務機關	職稱與時間
Asian Journal Control	編輯(1999-)
IEEE Trans. Fuzzy Systems	副編輯(2001-2006)
International J. Fuzzy Systems	總編輯(2005-2008)
Int. J. Control, Automation and Systems	Editorial Advisory Board(2003-迄今)
Fuzzy Set and Systems	Editorial Board(2006-迄今)
Int. J. Systems and Synthetic Biology	Editor-in-chief(2009-迄今)

五、 學術獎勵

1.國科會傑出研究獎4次(1988-1995)

2.國科會特約研究人員獎(1996-2006)

3.傑出人才發展基金會傑出人才獎座 (1999-2003)

4.中華民國自動控制學會第三屆傑出自動控制工程獎(2001)

5.國際電機電子工程學會IEEE Fellow(2001)

6.清華大學電機資訊講座教授(2003)

7.ISI論文高度引用學者(2005)

8.中華民國模糊學會第一屆傑出貢獻獎(2005)

9.IEEE Taipei Section第一屆最佳影響力獎(2006)

10.中華民國自動控制學會會士(2006)

11.教育部學術獎(2008)

12.有庠科技講座(通訊)(2010)

13.國科會學術攻頂計畫主持人(2010-2015)

14.2010國際基因工程設計競賽銀牌獎

六、 近年研究領域基本資料

Ⅰ.非線性隨機H∞強健性控制

非線性隨機非線性H∞強健性控制是控制理論及設計的最高境界，此種控制因必須考慮非線性、隨機雜訊、強健性，故為相當困難的問題。必須兼顧幾種領域的訓練及相當整合能力才能解決此種控制領域最困難的問題。陳博現教授與其以前的博士後張維海教授首先於2004年發表一篇線性隨機H2/ H∞強健性控制設計論文B.S. Chen and W. Zhang, “Stochastic H2/ H∞ control with state-dependent noise” IEEE Trans. Automatic Control, Vol. 49, No. 1, pp. 45-57, 2004.後，開始擴展到非線性方面的設計，並發表在控制理論最好的期刊W. Zhang and B.S. Chen, “State feedback H∞ control for a class of nonlinear stochastic systems” SIAM J. Control and Optimization, Vol. 44, No. 6, pp. 1973-1991, 2006.並探討隨機系統最廣泛的穩定及可偵測問題。W. Zhang, H. Zhang and B.S. Chen, “Generalized Lapunov equation approach to state-dependent stochastic detectability criterion” IEEE Trans. Automatic Control, Vol. 53, No. 7, pp.1630-1642, 2008. 同時亦探討相關的非線性H∞隨機濾波器設計，並發表於訊號處理最好期刊W. Zhang, B.S. Chen and C.S. Tseng, “Robust H∞ filtering for nonlinear stochastic systems” IEEE Trans. Signal Processing, Vol. 53, No. 2, pp. 589-599, 2005. 其後亦有幾篇相關非線性隨機非線性控制及濾波發表，並應用到量子系統的強健H∞追蹤控制，生物基因網路的分子雜訊放大及濾波原理探討基因及生化網路設計合成。陳博現教授研究室在非線性隨機系統的強健控制及濾波理論及應用是世界第一流的！

Ⅱ.無線網路的強健功率控制(power control of cellular systems)

無線網路的功率控制在通訊的品質及Q。S性能設計扮演非常重要的角色。只要mobile能維持理想的訊號對干擾及雜訊比(SINR)，就能維持良好的通訊品質。但在round-trip delay, channel fading, shadowing, 雜訊及其他cells的不確定干擾情況下，要能控制mobile的power，克服上述幾種不確定干擾，以維持理想的SINR不是簡單的設計工作。陳博現教授研究室以其在訊號處理及控制研究經驗，配合無線通訊的技術，近三年來共於IEEE Trans. Wireless Communication發表五篇一序列power control的regular papers如下：

1. B. S. Chen, B. K. Lee and S. K. Chen, "Adaptive power control of cellular CDMA systems via optimal prediction model" IEEE Trans. Wireless Communications, Vol. 4, No. 4, pp. 1914-1927, 2005.

2. B. K. Lee, H. W. Chen and B. S. Chen, "Power control of cellular radio systems via robust Smith prediction filter" IEEE Trans. Wireless Communications, Vol. 3, pp. 1822-1831, 2004.

3. B. K. Lee, Y. H. Chen and B. S. Chen, “Robust H∞ power control for CDMA cellular communication systems” IEEE Trans. Signal Processing, Vol. 54, No. 10, pp. 3947-3956, 2006.

4. B. S. Chen, B. K. Lee and Y. H. Chen, “Power control for CDMA cellular radio system via L1 optimal predictor” IEEE Trans. Wireless Communication, Vol. 5, No. 5, pp. 2914-2922, 2006.

5. B. S. Chen, T. Y. Yang and S. Y. Li, “Adaptive two-loop power tracking control with optimal net cost in CDMA communication systems” IEEE Trans. Wireless Communications, Vol. 7, No. 3, pp. 1-11, 2008.

因上面連續幾篇無線網路的power control重要論文發表，使我們儼然成為這方面研究的權威，大部分相關研究論文都會送來我們這裡審查。最近三年在手機定位研究亦有六篇IEEE Trans.的論文發表。另陳博現教授在訊號處理最好期刊IEEE Trans. Signal Processing十多年來亦發表二十幾篇regular papers，近五年來亦在IEEE Trans. Wireless Communications發表十篇左右的無線通訊regular papers，成果相當傑出。

Ⅲ.系統生物學

由於生物微晶片及high-throughput實驗大量數據充斥及生物資訊的發展，使得生物研究由傳統生物實驗研究轉型為系統生物研究時代。要完整及深入研究生物學必須結合生物、數學及工程等領域，並從動態系統的觀點才能瞭解真正的生物內在操作機制(mechanisms)和各種生物網路彼此之交互作用。也才能量化並測量生物系統的各種特性，如生物各層次網路的穩定度(stability)，敏感度(sensitivity)，強健度(robustness)，濾雜訊能力(filtering ability)，訊號傳遞能力(transduction ability)等。使生物不再是描述的科學而是系統的科學。目前各種生病或不正常的現象，都可視為生化網路的強健性降低，濾雜訊能力下降。因此將來藥物設計可視為如何增強強健性及抗外來雜訊的能力，就像工程強健設計類似。將來組合生物學(synthetic biology)希望能像電路設計一樣，事先開出一個生物網路的規格，然後用系統生物學的各種方法來設計出你想要的規格的生物系統出來。

目前陳博現教授在系統生物學的領域包含：

(1)從微晶片數據(micro array data)來建立基因網路模型，蛋白質交互作用網路模型，蛋白質調控基因表達之動態調控網路模型，癌細胞基因網路及蛋白質交互網路擾動模型，發炎反應的基因網路模型，細胞分裂之週期網路模型，果蠅發育胚胎調控3D網路模型。

(2)基因網路及蛋白質網路強健性的量測。基因網路分子雜訊的放大與濾波原理，生物訊號傳遞能力。基因強健調控電路設計，基因強健濾波電路設計。從系統生物學探討藥物設計。組合生物網路設計。

(3)生物網路演化研究，動態博局理論在生態網路的研究。

(4)基因電路合成設計研究，利用控制系統及訊號濾波理論來合成想要的生物網路。

近年來陳博現教授研究室已在系統生物學領域發表25篇左右的論文，每篇論文都極受歡迎。BMC Bioinformatics的總編輯都來道賀我們的論文都是被significant access.其中B.S. Chen and Y.C. Wang, “On the attenuation and amplification of molecular noise in genetic regulatory networks” BMC Bioinformatics, 7:52, 1-14, 2006.一文備受讚揚。基因網路如何處理內外在的molecular noise而使機能正常運轉是系統生物學一個重要研究主題。我們用非線性隨機的控制及濾波來印證，解釋。被視為重大突破，並可應用來設計基因電路來增強基因網路的robustness及filtering ability。GenWay Biotech來信讚揚我們的論文在cell communication重要成果。另Nature期刊的Nature Network team因我們這篇論文來函要我們加入他們Nature Network參加他們online meeting。另陳博現教授被邀請寫一篇如何用micro array data及systems biology的方法設計藥物的文章。B.S. Chen and C.W. Li, “Analyzing micro array data in drug discovery using system biology” Expert Opinion on Drug Discovery, Vol. 2, No. 5, pp. 755-768, 2007. 最近陳博現有兩篇基因網路的強健性設計論文將會是相關基因電路設計領域的新里程：B.S. Chen, W.S. Wu, Y.C. Wang and W.H. Li, “On the robust circuit design systems of biochemical networks: steady state approach” IEEE Trans. Biomedical circuits and systems, Vol. 1, pp. 91-104, 2007.(此一論文一刊登，馬上接到CMOS ET2008 Workshop的 Technical Chairman Kris Iniewski邀請演講，他希望半導體電路在生化電路這方面有可能機會) B.S. Chen, Y.T. Chang and Y.C. Wang, “Robust H∞ molecular noise filter design in gene networks: fuzzy interpolation approach” IEEE Trans. System, Man and Cybernetics part B: Cybernetics, Special Issue for Systems Biology, Vol.38, pp. 25-42, 2008. B. S. Chen and Wu. W. S. ”On the robust gene circuit design of gene networks under intrinsic noise and extrinsic noise” Mathematical Biosciences, Vol. 211, No. 2, pp. 342-355, 2008. B. S. Chen and P. W. Chen, ”Robust engineered circuit design principles for stochastic biochemical network with parameter uncertainties and disturbance” IEEE Transactions on Biomedical Circuits and Systems Vol. 2, No. 2, pp. 114-132, 2008. 將來會在bio-synthetic network design及engineered bio-circuit design等領域起重大作用。目前陳教授較注意於強健合成生物學(robust synthetic biology), 已有六篇論文發表。如B. S. Chen, C. H. Chang and H. C. Lee, “Robust synthetic biology design: stochastic game theory approach” Bioinformatics, 25(14), 1822-1830, 2009、B. S. Chen and C. H. Wu, “A systematic design method for robust synthetic biology to satisfy design specifications” BMC Systems Biology, 3:66, 2009、C. H. Wu, W. Zhang and B. S. Chen, “Multiobjective H2/H∞ synthetic gene network design based on promoter libraries” Mathematical Biosciences, 233(2), 111-125, 2011、C. H. Wu, H. C. Lee and B. S. Chen, “Robust synthetic gene network design via library-based search method” Bioinformatics, 27(19), 2700-2706, 2011。

目前陳博現研究室與生科院藍忠昱、莊永仁兩位教授，統計所謝文萍教授，化工系汪上曉教授，資工系唐傳義教授，組織一個生物資訊及系統生物學研究團隊，目前亦與交大盧鴻星教授及李曉青教授，芝加哥大學李文雄院士加強合作，相信陳博現系統生物研究室，將是世界第一流的系統生物研究團隊。台灣生物界必要有相關工程背景人員參與研究，才能由試管層次提升到系統及工程層次。另由國科會學術攻頂計畫補助成立「基因電路設計實驗室」，培養生物基因電路設計人才，再結合台灣半導體電路及IC設計優秀能力，台灣的生物產業才能真正落實及壯大。

七、人力、經費投入情形

本研究室有九個博士班學生，八個碩士班學生，兩個博士後，四個研究助理，研究經費一年約一百五百餘萬。

八、2010年計畫與預算執行情形

主持一個國科會五年期的學術攻頂計畫「用系統工程方法設計強健生物IC電路」2010~2015，五年總共八千萬台幣，並成立「基因電路設計實驗室」。

九、出版目錄（2006年以後）

- a. Control and System:

1. W. Zhang and B. S. Chen, “State feedback H∞ control for a class of nonlinear stochastic systems,” SIAM J. on Control and Optimization, Vol. 44, No. 6, pp.1973-1991, 2006.

2. W. Zhang, H. Zhang and B. S. Chen, “Stochastic H2/H∞ control with (x,u,v)-dependent noise: Finite horizon case,” Automatica, Vol. 42, No. 11, pp.1891-1898, 2006.

3. W. Zhang, H. Zhang and B. S. Chen, ”Generalized Lyapunov equation approach to state-dependent stochastic stabilization/detectability Criterion,” IEEE Trans. Automatic Control, Vol. 53, No. 7, pp.1630-1642, 2008.

4. W. Zhang and B. S. Chen, ”Stochastic affine quadratic regulator with applications to tracking control of quantum systems,” Automatica, Vol. 44, No. 11, pp. 2869-2875, 2008.

5. Y. Y. Chen, Y. T. Chang and B. S. Chen, “Fuzzy solution to partial differential equation: adaptive approach” IEEE Trans. Fuzzy Systems, Vol. 17, No. 1, pp. 116-127, 2009..

6. C. S. Tseng and B. S. Chen, “Robust fuzzy observer-based fuzzy control design for nonlinear discrete time system with persistent bounded disturbances” IEEE Trans. Fuzzy Systems, Vol. 17, No. 3, pp. 711-723, 2009.

7. B. S. Chen and Y. T. Chang, “Fuzzy state space modeling and robust observer-based control design for nonlinear partial differential systems” IEEE Trans. Fuzzy Systems (in press).

8. C. S. Tseng, B. S. Chen and Y. F. Li, “Robust fuzzy observer-based fuzzy control design for nonlinear systems with persistent bounded disturbances: A novel decoupled approach” Fuzzy Sets and Systems, Vol. 160, No. 19, pp. 2824-2843, 2009.

9. Y. T. Chang and B. S. Chen, “A fuzzy approach for robust reference tracking control design of nonlinear distributed parameter time-delayed systems and its application” IEEE Trans. Fuzzy Systems, Vol. 18, No. 6, pp. 1041-1057, 2010.

10. B. S. Chen, C. H. Chiang and S. K. Nguang “Robust H∞ synchronization design of nonlinear coupled network via fuzzy interpolation method” IEEE Trans. Circuit and System I, Vol. 58, No. 2, pp. 349-362, 2011.

- b. Signal Processing and Communication:

1. T. J. Ho & B. S. Chen, “Novel extended Viterbi-based multiple-model algorithms for state estimation of discrete-time systems with Markov jump parameters,” IEEE Trans. on Signal Processing, Vol. 54, No. 2, 393-404, 2006.

2. T. J. Ho and B. S. Chen, “Tracking of dispersive DS-CDMA channels: An AR-embedded modified interacting nultiple-model approach,” IEEE Trans. Wireless Communications, Vol. 6, No. 1, pp. 166-174, 2007.

3. B. K. Lee, Y. H. Chen and B. S. Chen, “Robust H∞ power control for CDMA cellular communication systems,” IEEE Trans. Signal Processing Vol. 54, No. 10, 3947-3956, 2006.

4. B. S. Chen, B. K. Lee and Y. H. Chen, “Power control for CDMA cellular radio system via L1optimal predictor,” IEEE Trans. Wireless Communication, Vol. 5, No. 10, 2914-2922, 2006.

5. J. F. Liao and B. S. Chen, “Robust mobile location estimator with NLOS mitigation using interacting multiple model algorithm,” IEEE Trans. Wireless Communication, Vol. 5, No. 11, 3002-3006, 2006.

6. B. S. Chen, C. Y. Yang and S. Y. Li, “Adaptive two-loop power tracking control in CDMA systems with utility optimization” IEEE Trans. Wireless Communications, Vol. 7, No. 4, 1358-1368, 2008.

7. B. S. Chen and J. F. Liao, “Adaptive MC-CDMA multiple channel estimation and tracking over time-varying multiple fading channels,” IEEE Trans. Wireless Communications, Vol.6, No. 6, 2328-2337, 2007.

8. J. F. Liao and B. S. Chen, ”A new full-diversity blind channel estimation and equalization over fast time-varying ISI fading channel,” IEEE Trans. Wireless Communication, Vol. 7, No. 11, pp. 4070-4075, 2008.

9. B. S. Chen, C. Y. Yang, F. K. Liaw and J. F. Liao, ”Mobile location estimator in rough wireless environment using extended Kalman-based IMM and data fussion” IEEE Vehicular technology, Vol. 53, No. 3, pp. 1157-1169, 2009.

10. B. S. Chen, W. H. Chen and H. L. Wu, “Robust H2/H∞ global linearization filter design for nonlinear stochastic systems” IEEE Trans. Circuit and System I, Vol. 56, No. 7, pp. 1441-1454, 2009.

11. W. Y. Chiu and B. S. Chen, “Mobile location estimation in urban areas using mixed Manhattan/Euclidean norms and convex optimizations” IEEE Trans. Wireless Communications, Vol. 8, No. 1, pp. 414-423, 2009.

12. W. Y. Chiu and B. S. Chen, “Mobile positioning problem in the Manhattan-like urban areas: Uniqueness of solution, optimal deployment of BSs, and fuzzy implementation” IEEE Trans. Signal Processing, Vol. 57, No. 12, pp. 4918-4929, 2009.

13. C. Y. Yang and B. S. Chen, “Robust power control of CDMA cellular radio systems with time-varying delays” Signal Processing, Vol. 90, No. 1, pp. 363-372, 2010.

14. W. Y. Chiu and B. S. Chen, “A mixed-norm approach using simulated annealing with changeable neighborhood for mobile location estimation” IEEE Trans. mobile computation, Vol. 9, No. 5, pp. 633-642, 2010.

15. C. Y. Yang, F.K. Liao and B. S. Chen, “Mobile location estimation using fuzzy-based IMM and data fusion” IEEE Trans. Mobile Computing, Vol. 9, No. 10, pp. 1424-1436, 2010.

16. T. J. Ho and B. S. Chen, “Robust minimax MSE equalizer designs for MIMO wireless communications with time-varying channel uncertainties” IEEE Trans. Signal Processing, Vol. 58, No. 11, pp. 5835-5844, 2010.

17. C. Y. Yang and B. S. Chen, “Adaptive channel-tracking method and equalization for MC-CDMA systems over rapidly fading channel under colored noise” EURASIP Journal on Advances in Signal Processing, Vol. 2010, Article ID 871650, 2010.

18. C. Y. Yang and B. S. Chen, “Robust MC-CDMA channel tracking for fast time-varying multipath fading channel” IEEE Trans. Vehicular technology, Vol. 59, No. 9, pp. 4658-4664, 2010.

19. W. Y. Chiu and B. S. Chen, “Multisource prediction under nonlinear dynamics in WSNs using a robust fuzzy approach” IEEE Trans. Circuit and System I, Vol. 58, No. 1, pp. 137-149, 2011.

20. W. Y. Chiu, B. S. Chen and C. Y. Yang, “Robust relative location estimation in wireless sensor networks with inexact position problem” IEEE Trans. Mobile Computing (in press).

21. W. H. Chen and B. S. Chen, “Robust filter for linear stochastic partial differential systems via a set of sensor measurements” IEEE Trans. Circuit and System I (in press).

- c. Systems Biology and Bioinformatics

1. B. S. Chen and Y. C. Wang, “On the attenuation and amplification of molecular noise in genetic regulatory networks” BMC Bioinformatics, 7:52, 1-14, 2006.

2. H. C. Chen, H. C. Lee, T. Y. Lin and B. S. Chen, “Stabilization control of small heat shock proteins in cellular chaperone protection systems” Journal of the Chinese Institute of Engineers, Vol.29, No.2, pp.364-373, 2006.

3. Y. H. Chang, Y. C. Wang, and B. S. Chen, “Identification of transcription factor cooperativity via stochastic system model” Bioinformatics, Vol.22, No.18, pp.2276-2282, 2006.

4. W. S. Wu, W. H. Li, and B. S. Chen, “Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle” BMC Bioinformatics 7:421, 2006.

5. C. W. Li, Y. H. Chu, and B. S. Chen, “Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data” Cancer Informatics, 2, 223-241, 2006.

6. B. S. Chen, W. S. Wu, W. S. Wu, and W. H. Li, “On the adaptive design rules of biochemical network in evolution” Evolutionary Bioinformatics, 2, 27–39, 2007.

7. B. S. Chen and C. W. Li, “Analyzing microarray data in drug discovery using systems biology” Expert Opinion on Drug Discovery Vo2, No.5, pp.755-768, 2007.

8. W. S. Wu, W. H. Li and B. S. Chen, “Identifying regulatory targets of cell cycle transcription factors using gene expression and ChIP-chip data” BMC Bioinformatics 8:188, 2007.

9. B. S. Chen and W. S. Wu, “Underlying principles of natural selection in network evolution: systems biology approach” Evolutionary Bioinformatics, 3, 245-262, 2007.

10. Y. H. Chang, Y. C. Wang, and B. S. Chen, “Nonlinear dynamic trans/cis regulatory circuit for gene transcription via microarray data” Gene Regulation and Systems Biology, 1, 151-166, 2007.

11. W. S. Wu and B. S. Chen, “Identifying stress transcription factors using gene expression and TF-gene association data” Bioinformatics and Biology Insights, 1, 9-17, 2007.

12. B. S. Chen, W. S. Wu, Y. C. Wang, and W. H. Li, “On the robust circuit design schemes of biochemical networks: steady-state approach” IEEE Transactions on Biomedical Circuits and Systems, Vol. 1, No. 2, 91-104, 2007.

13. B. S. Chen, Y. T. Chang and Y. C. Wang, “Robust H∞-stabilization design in gene networks under stochastic molecular noises: fuzzy-interpolation approach” IEEE Transactions on System, Man and Cybernetics Part B: Cybernetics , Vol. 38, No. 1, 25-42, 2008.

14. B. S. Chen and W. S. Wu, “Robust filtering circuit design for stochastic gene networks under intrinsic and extrinsic molecular noises” Mathematical Biosciences, Vol. 211, No. 2, 342-355, 2008.

15. L. H. Lin, H. C. Lee, W. H. Li and B. S. Chen, “A systematic approach to detecting transcription factors in response to environmental stresses” BMC Bioinformatics 8:473, 2007.

16. W. S. Wu, W. H. Li and B. S. Chen, “Reconstructing a network of stress-response regulators via dynamic system modeling of gene regulation” Gene Regulation and Systems Biology, 2, 53-62, 2008.

17. L. H. Chu and B. S. Chen, “Comparisons of robustness and sensitivity between cancer and normal cells via microarray data” Cancer Informatics, 4, 165-181, 2008.

18. L. H. Chu and B. S. Chen, “Construction of cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets” BMC Systems Biology, 2:56, 2008.

19. B. S. Chen and C. H. Chang and Y. J. Chuang, “Robust model matching control of immune systems under environmental disturbances: dynamic game approach” Journal of Theoretical Biology, 253, 824-837, 2008.

20. B. S. Chen and P. W. Chen, ”Robust engineered circuit design principles for stochastic biochemical network with parameter uncertainties and disturbance” IEEE Transactions on Biomedical Circuits and Systems, Vol. 2, No. 2, 114-132, 2008.

21. B. S. Chen, S. K. Yang, C. Y. Lan and Y. J. Chuang, “A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining” BMC Medical Genomics, 1:46, 2008.

22. B. S. Chen and Y. T. Chang, “A systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises” BMC Systems Biology 2:103, 2008.

23. T. Chen, F. Li and B. S. Chen, “Cross-talks of sensory transcription networks in response to various environmental stresses” Interdisciplinary Sciences: Computational Life Sciences, 1, 46-54, 2009.

24. B. S. Chen, C. H. Chang and H. C. Lee, “Robust synthetic biology design: stochastic game theory approach” Bioinformatics, Vol.25, No.14, pp.1822-1830, 2009.

25. B. S. Chen and C. H. Wu, “A systematic design method for robust synthetic biology to satisfy design specifications” BMC Systems Biology, 3:66, 2009.

26. B. S. Chen and P. W. Chen, “On the estimation of robustness and filtering ability of dynamic biochemical networks under process delays, internal parametric perturbations and external disturbances” Mathematical Biosciences, 222(2), 92-108, 2009.

27. C. W. Li and B. S. Chen, “Stochastic spatio-temporal dynamic model for gene/protein interaction network in early Drosophila development ” Gene Regulation and Systems Biology, 3, 191-210, 2009.

28. B. S. Chen and C. W. Li, “On the noise enhancing ability of stochastic Hodgkin-Huxley neuron systems” Neural Computation, 22(7), 1737-1763, 2010.

29. Y. C. Wang, C. Y. Lan, W. P. Hsieh, L. Murillo, N. Agabian and B. S. Chen, “Global screening of potential Candida albicans biofilm-related transcription factors via network comparison” BMC Bioinformatics, 11:53, 2010.

30. C. W. Li and B. S. Chen, “Identifying functional mechanisms of gene and protein regulatory networks in response to a broader range of environmental stresses” Comparative and Functional Genomics, Vol. 2010, Article ID 408705, 2010.

31. Y. C. Wang and B. S. Chen, “Integrated cellular network of transcription regulations and protein-protein interactions” BMC Systems Biology, 4:20, 2010.

32. B. S. Chen and P. W. Chen, “GA-based design algorithms for the robust synthetic genetic oscillators with prescribed amplitude, period and phase” Gene Regulation and Systems Biology, 4, 35-52, 2010.

33. B. S. Chen and C. W. Li, “On the interplay between entropy and robustness of gene regulatory networks” Entropy, 12(5), 1071-1101, 2010.

34. S. K. Yang, Y. C. Wang, C. C. Chao, Y. J. Chuang, C. Y. Lan and B. S. Chen, “Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFalpha-induced inflammatory responses” BMC Medical Genomics, 3:19, 2010.

35. B. S. Chen and C. W. Li, “Robust observer-based tracking control of Hodgkin-Huxley neuron systems under environmental disturbances” Neural Computation, 22(12), 3143-3178, 2010.

36. B. S. Chen and C. H. Wu, “Robust optimal reference tracking design method for stochastic synthetic biology systems: T-S fuzzy approach” IEEE Trans. Fuzzy Systems, 18(6), 1144-1159, 2010.

37. Y. C. Wang and B. S. Chen, “A network-based biomarker approach for molecular investigation and diagnosis of lung cancer” BMC Medical Genomics, 4:2, 2011.

38. B. S. Chen, C. H. Chang, Y. C. Wang, C. H. Wu and H. C. Lee, “Robust model matching design methodology for a stochastic synthetic gene network” Mathematical Biosciences, 230(1), 23-36, 2011.

39. P. W. Chen and B. S. Chen, “Robust synchronization analysis in nonlinear stochastic cellular networks with time-varying delays, intracellular perturbations and intercellular noises” Mathematical Biosciences, 232(2), 116-134, 2011.

40. C. H. Wu, W. Zhang and B. S. Chen, “Multiobjective H2/H∞ synthetic gene network design based on promoter libraries” Mathematical Biosciences, 233(2), 111-125, 2011.

41. C. H. Wu, H. C. Lee and B. S. Chen, “Robust synthetic gene network design via library-based search method” Bioinformatics, 27(19), 2700-2706, 2011.

42. B. S. Chen, Y. P. Lin and Y. J. Chuang, “Robust H∞ observer-based tracking control of stochastic immune systems under environmental disturbances and measurement noises” Asian Journal of Control, 13(5), 667-690, 2011.

43. C. W. Yao, B. D. Hsu and B. S. Chen, “Constructing gene regulatory networks for long term photosynthetic light acclimation in Arabidopsis thaliana” BMC Bioinformatics, 12:335, 2011.

44. B. S. Chen, C. Y. Hsu and J. J. Liou, “Robust design of biological circuits: Evolutionary systems biology approach” Journal of Biomedicine and Biotechnology, Vol. 2011, Article ID 304236, 2011.

45. B. S. Chen and Y. P. Lin, “Robust resource management control for CO2 emission and reduction of greenhouse effect: stochastic game approach” Journal of Environmental Protection, 2, 1172-1191, 2011.

46. B. S. Chen and Y. P. Lin, “On the interplay between the evolvability and network robustness in an evolutionary biological network: A systems biology approach” Evolutionary Bioinformatics, 7, 201-233, 2011.

十、主持人成就

陳博現教授在控制系統，訊號與通訊，系統生物學及生物資訊三個領域互為表裡，學術整合，成果相當傑出。陳博現教授的研究主題在於：如何在系統內在擾動及外在環境干擾下，從事系統設計來容忍內在擾動，濾掉外在干擾，並達成設計目標。從理論觀點來探討，立論嚴謹。並應用到機械人及工具機控制、飛彈、人造衛星導航控制、無線通訊系統及訊號傳輸系統的濾波及訊號重建、基因網路重建及強健性設計。目前論文被SCI期刊引用約4000次，其中八篇超過百次，另有六篇是最近十年內論文是SCI的highly cited(前1%)論文。是台灣電機領域居領先地位者，因在台灣IEEE members中論文被引用次數最多而獲得2006年首屆IEEE TAIPEI SECTION的最佳影響力獎。憑藉我們在控制系統設計理論的堅強實力，訊號通訊系統方面優勢能力及生物方面的廣闊知識（陳教授旁聽十幾門生物相關課程及親自上五門生物相關課程），使我們實驗室的系統生物學及合成生物學研究在台灣首屈一指，各種基因及蛋白質網路重建方法及各種網路設計方法在世界領先。　